Cyproheptadine /ˌsaɪprɵˈhɛptədiːn/, sold under the brand name Periactin or Peritol, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties.
Cyproheptadine is used to treat allergic reactions (specifically hay fever).
Has shown effectiveness in the treatment of nightmares including nightmares related to post traumatic stress disorder..
Has been used in the management of moderate to severe cases of serotonin syndrome, a complex of symptoms associated with the use of serotonergic drugs, such as selective serotonin reuptake inhibitors and monoamine oxidase inhibitors), and in cases of hyperserotoninaemia resulting from a serotonin-producing carcinoid tumor.
Can also be used as a preventive measure against migraine in children and adolescents. In Australia this is the only indication for which cyproheptadine is subsidised by the PBS.
Can relieve SSRI-induced sexual dysfunction and drug-induced hyperhidrosis (excessive sweating).
Also used in the treatment of cyclical vomiting syndrome.
Long-term use of the drug can stimulate the appetite and may lead to weight gain, which is helpful for underweight people.
According to a small study, cyproheptadine hydrochloride has been found to improve sleep, calmness, as well as mood and energy levels, and to improve both negative and (sometimes even) positive psychotic symptoms in a subgroup of chronic schizophrenics who do not respond (either completely or sufficiently) to other therapies.
Cyproheptadine may improve akathisia in patients on antipsychotic medications.
In clinical trials in which cyproheptadine was used as an adjunct to antipsychotic treatment for patients with schizophrenia, an improvement in negative symptoms was seen.